Design and targeted reactions of oligonucleotide derivatives

摘要: Antisense oligonucleotides represent a new paradigm for drug delivery, employing class of chemicals to intervene in biological processes that have not been used as sites action. This book places antisense the context discovery and development, reviewing current status research drugs discussing strategies future challenges opportunities. It presents several approaches, emphasizing preparation, investigation, applications reactive derivatives oligonucleotides. Specific topics covered include reagents able modify nucleic acids or oligonucleotides, possible structural kinetic problems. Biological oligonucleotide are considered well.