Aging, genomic entropy and carcinogenesis: implications derived from longitudinal age-specific colon cancer mortality rate dynamics

摘要: Abstract Many types of cancer are intrinsically linked to the process aging. Aging, from perspective second law thermodynamics, can be viewed as associated with inevitable and natural increase in informational entropy genome. The molecular biologic basis increasing genetic information is inherent variable instability different regions Colon cells have been shown characteristic acquired abnormalities, most commonly, deletions presumed tumor suppressor genes. Age-specific colon mortality rates US 1958 1988 were subjected longitudinal Gompertzian analysis, a method that may identify distinguish among genetic, environmental competitive influences upon mortality. Strehler-Mildvan modification Gompertz relationship between aging used determine relative measure rate (a reflection instability) for those factors involved pathogenesis cancer.