The ctnG gene encodes carbonic anhydrase involved in mycotoxin citrinin biosynthesis from Monascus aurantiacus
作者： Yan-Ping Li , Xiao Tang , Wei Wu , Yang Xu , Zhi-Bing Huang
DOI: 10.1080/19440049.2014.990993
关键词:
摘要: Citrinin, a fungal secondary metabolite of polyketide origin, is moderately nephrotoxic to vertebrates, including humans. Citrinin synthesised by condensation acetyl-CoA and malonyl-CoA. Six genes involved in the citrinin biosynthesis, pksCT, ctnA ctnB, have been cloned Monascus purpureus. The pksCT gene encodes synthase; regulatory factor; ctnB an oxidoreductase. When three were respectively disrupted, disruption strains drastically decreased production or barely produced citrinin. Ten new discovered aurantiacus besides above six genes. One these displayed highest similarity β-carbonic anhydrase from Aspergillus oryzae (74% similarity) was designated ctnG. To learn more about biosynthetic pathway, ctnG-replacement vector constructed disrupt ctnG with hygromycin resistance as selection marker, then transformed into M. Li...
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