Regulation of plasma levels of aldosterone and its metabolites during the latent period of aldosterone

摘要: Abstract Castration of male rats led to both increased biliary excretion aldosterone metabolites and clearance radiometabolites from the plasma at rates similar those intact females elimination previously observed sex-dependence these processes. Ovariectomy female did not cause any effects in Treatment castrated ovariectomized with testosterone reintroduced so that were cleared excreted via bile animals a slower rate typical males. These findings suggest presence androgens plays major role regulating routes hepatic metabolism aldosterone, subsequent hence concentration composition attained during latent period hormone. Hypophysectomy femalerats significantly altered typically However, hypophysectomy changes either two an pituitary is required for processes rats.