Mechanisms of Acetaminophen-Induced Liver Necrosis
作者： Jack A. Hinson , Dean W. Roberts , Laura P. James
DOI: 10.1007/978-3-642-00663-0_12
关键词:
摘要: … acetaminophen liver injury is controversial. Ray and coworkers reported that following a toxic dose of acetaminophen … to confirm that acetaminophen caused apoptosis in livers of mice …
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Laurie D. Deleve, Xiangdong Wang, Neil Kaplowitz, Howard M. Shulman, Jannette A. Bart, Airenne Van Der Hoek, Sinusoidal endothelial cells as a target for acetaminophen toxicity direct action versus requirement for hepatocyte activation in different mouse strains Biochemical Pharmacology. ,vol. 53, pp. 1339- 1345 ,(1997) , 10.1016/S0006-2952(97)00048-8
A. L. Nieminen, A. M. Byrne, B. Herman, J. J. Lemasters, Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species American Journal of Physiology-cell Physiology. ,vol. 272, ,(1997) , 10.1152/AJPCELL.1997.272.4.C1286
T. J. Bucci, T. A. McRae, D. W. Roberts, R. W. Benson, J. A. Hinson, A. R. Warbritton, N. R. Pumford, Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. American Journal of Pathology. ,vol. 138, pp. 359- 371 ,(1991)
Patty J. Donnelly, Robin M. Walker, William J. Racz, Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity Archives of Toxicology. ,vol. 68, pp. 110- 118 ,(1994) , 10.1007/S002040050043
Pennypacker Kr, Bruccoleri A, Blazka Me, Simeonova P, Germolec Dr, Luster Mi, Acetaminophen-induced hepatotoxicity is associated with early changes in NF-kB and NF-IL6 DNA binding activity. Journal of Inflammation. ,vol. 47, pp. 138- 150 ,(1995)
Hepatic damage from overdose of paracetamol. Gut. ,vol. 13, pp. 836- 836 ,(1972) , 10.1136/GUT.13.10.836
M A Tirmenstein, S D Nelson, Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver Journal of Biological Chemistry. ,vol. 264, pp. 9814- 9819 ,(1989) , 10.1016/S0021-9258(18)81731-8
Arthur I. Cederbaum, CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury. Mount Sinai Journal of Medicine. ,vol. 73, pp. 1- 36 ,(2008) , 10.1007/978-0-387-77300-1_6
Randle M Gallucci, Petia P Simeonova, Wataru Toriumi, Michael I Luster, None, TNF-α Regulates Transforming Growth Factor-α Expression in Regenerating Murine Liver and Isolated Hepatocytes The Journal of Immunology. ,vol. 164, pp. 872- 878 ,(2000) , 10.4049/JIMMUNOL.164.2.872
M. Tamura, N. Arakaki, H. Tsubouchi, H. Takada, Y. Daikuhara, Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture. Journal of Biological Chemistry. ,vol. 268, pp. 8140- 8145 ,(1993) , 10.1016/S0021-9258(18)53072-6