The reverse-direction method links mass experimental data to human diseases.

摘要: Genome-wide analyses such as DNA microarray, RNA sequencing and interference-based high-throughput screening are prevalent to decipher a biological process of interest, provide large quantity data be processed. An ultimate goal for researchers must extrapolation their human diseases. We have conducted functional genome-wide screenings elucidate molecular mechanisms the inflammation amplifier, NFκB/STAT3-dependent machinery that potently drives recruitment immune cells promote inflammation. Using public database association studies (GWAS), we recently reported reverse-direction method by which our mass were successfully linked many As an example, epiregulin-epidermal growth factor receptor pathway was identified regulator associated with diseases GWAS. In fact, serum epiregulin levels higher in patients chronic inflammatory disorders. The can useful tool narrow down focus on disease-related genes.