Disease-Association Analysis of an Inflammation-Related Feedback Loop
作者： Masaaki Murakami , Masaya Harada , Daisuke Kamimura , Hideki Ogura , Yuko Okuyama
DOI: 10.1016/J.CELREP.2013.01.028
关键词:
摘要: The IL-6-triggered positive feedback loop for NFκB signaling (or the IL-6 amplifier/Inflammation amplifier) was originally discovered as a synergistic-activation signal that follows IL-17/IL-6 stimulation in nonimmune cells. Subsequent results from animal models have shown amplifier is activated by of and STAT3 induces chemokines inflammation via an loop. However, its role human diseases unclear. Here, we combined two genome-wide mouse screens with SNP-based disease association studies, revealing 1,700 genes related to amplifier, 202 which showed 492 indications ailments beyond autoimmune diseases. We followed up on ErbB1 our list. Blocking suppressed whereas expression epiregulin, ligand, higher patients inflammatory These indicate indeed associated disorders identified may make potential therapeutic targets.
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