Significance of circulatory DPP4 activity in metabolic diseases.

摘要: Dipeptidyl peptidase 4 (DPP4), also known as CD26 is a type II transmembrane protein that released from the cell membrane in nonclassical secretory mechanism. This exopeptidase selectively degrades varieties of substrates including incretin hormones, growth factors, and cytokines. A significant detectable amount DPP4 activity can be measured plasma well different tissues such intestinal epithelium, vascular endothelium, lymphocytes, monocytes, kidney, liver, adipose, lung, thymus, spleen, prostate, etc. Enzymatically active circulatory shed via proteolytic cleavage, process responsible for enhanced levels activity. Elevated has been found wide spectrum metabolic diseases diabetes, obesity, cardiovascular diseases, nonalcoholic fatty liver diseases. Moreover, recent preclinical studies have further expanded repertoire usage inhibitors treatment other their consequent complications. In present review we highlight reason behind elevated with focus on tissue origin. We underscore discrepancy enzyme © 2018 IUBMB Life, 70(2):112-119, 2018.