Hepatitis B virus genotype change in children is closely related to HBeAg/anti-HBe seroconversion.

摘要: BACKGROUND AND OBJECTIVES Genotype changes have been observed during long-term follow-up in adults with chronic hepatitis B virus (HBV) infection. The aim of this study was to assess the frequency and distribution HBV genotype shifts treated untreated European children different phases B. METHODS initial population consisted 85 HBeAg-positive who were sequentially investigated for genotypes a mean period 7.1 years. During survey, 65 patients seroconverted anti-HBe 24 received antiviral treatment. Genotyping done by restriction fragment length polymorphism. RESULTS Genotypes at enrollment distributed as follows: D (n = 67), A 11), 4), C mixed 3). change 16 (19%) participants last visit, whom 1 20 (5%) remained persistently HBeAg positive 15 (23%) had (P < 0.001). shift or 9 individuals, 5, 1. more frequent than subjects; however, difference not statistically significant. CONCLUSIONS results suggest that is relatively event after seroconversion independent reasons why only some will experience remain be clarified.