Impaired Release of ATP from Red Blood Cells of Humans with Primary Pulmonary Hypertension

摘要: Previously, we reported that in the isolated perfused rabbit lung, red blood cells (RBCs) obtained from either rabbits or healthy humans were a required component of perfusate to unmask evidence nitric oxide (NO) participation regulation pulmonary circulation. In addition, found mechanical deformation and human RBCs released ATP, known agonist for enhanced NO synthesis. contrast, patients with cystic fibrosis (CF) did not release ATP response deformation. The coexistence airway disease alveolar hypoxia CF precluded drawing conclusions relating defect RBC hypertension associated CF. Airway are not, however, features primary (PPH), condition unknown etiology. We postulated generation might contribute increased vascular resistance PPH, as first ...