EDRF generation and release from perfused bovine pulmonary artery and vein.
作者： Louis J. Ignarro , Georgette M. Buga , Gautam Chaudhuri
DOI: 10.1016/0014-2999(88)90045-3
关键词:
摘要: Abstract A bioassay cascade superfusion procedure was utilized to study the release and effects of endothelium-derived relaxing factor (EDRF) from isolated bovine pulmonary artery vein. Three precontracted, endothelium-denuded strips or vein mounted in series served as detector EDRF. Perfusion with acetylcholine, bradykinin A23187, presence indomethacin, caused EDRF ( t 1 2 = 3−5 s ) which relaxed superfused both Similarly, perfusion but not artery. EDRF-elicited vascular smooth muscle relaxation associated cyclic GMP accumulation strips. activity increased its duration prolonged by superoxide dismutase low oxygen tension, whereas oxyhemoglobin methylene blue were markedly inhibitory. The similar patterns release, instability, properties intact suggest that arterial venous are closely similar.
elsevier.com
sci-hub.se 参考文章(32)
Ignarro L, Barry Bk, Gruetter Ca, McNamara Db, Kadowitz Pj, Gruetter Dy, Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. Journal of cyclic nucleotide research. ,vol. 5, pp. 211- ,(1979)
L J Ignarro, J B Adams, P M Horwitz, K S Wood, Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms. Journal of Biological Chemistry. ,vol. 261, pp. 4997- 5002 ,(1986) , 10.1016/S0021-9258(19)89205-0
G. M. Rubanyi, P. M. Vanhoutte, Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 250, ,(1986) , 10.1152/AJPHEART.1986.250.5.H822
A L Hyman, M S Wolin, L J Ignarro, R G Harbison, D B McNamara, K S Wood, P J Kadowitz, Differences in responsiveness of intrapulmonary artery and vein to arachidonic acid: mechanism of arterial relaxation involves cyclic guanosine 3':5'-monophosphate and cyclic adenosine 3':5'-monophosphate Journal of Pharmacology and Experimental Therapeutics. ,vol. 233, pp. 560- 569 ,(1985)
L J Ignarro, R G Harbison, K S Wood, P J Kadowitz, Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. Journal of Pharmacology and Experimental Therapeutics. ,vol. 237, pp. 893- 900 ,(1986)
H Lippton, A L Hyman, C A Gruetter, L J Ignarro, W H Baricos, P J Kadowitz, J C Edwards, Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. Journal of Pharmacology and Experimental Therapeutics. ,vol. 218, pp. 739- 749 ,(1981)
P J Kadowitz, M S Wolin, T M Burke, L J Ignarro, K S Wood, Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery. Journal of Pharmacology and Experimental Therapeutics. ,vol. 228, pp. 682- 690 ,(1984)
A L Hyman, L J Ignarro, P J Kadowitz, J C Edwards, Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP. Journal of Pharmacology and Experimental Therapeutics. ,vol. 228, pp. 33- 42 ,(1984)
Carl A. Gruetter, Sally M. Lemke, Bradykinin-induced endothelium-dependent relaxation of bovine intrapulmonary artery and vein European Journal of Pharmacology. ,vol. 122, pp. 363- 367 ,(1986) , 10.1016/0014-2999(86)90418-8
D. Regoli, J. Mizrahi, P. D'Orléans-Juste, S. Caranikas, Effects of kinins on isolated blood vessels. Role of endothelium. Canadian Journal of Physiology and Pharmacology. ,vol. 60, pp. 1580- 1583 ,(1982) , 10.1139/Y82-234