Depression in small-vessel disease relates to white matter ultrastructural damage, not disability

摘要: Objective: To determine whether cerebral small-vessel disease (SVD) is a specific risk factor for depression, any association mediated via white matter damage, and to study the role of depressive symptoms disability on quality life (QoL) in this patient group. Methods: Using path analyses cross-sectional data, we modeled relationships among disability, QoL patients with SVD presenting radiologically confirmed lacunar stroke (n = 100), replicated results second cohort 100). We then compared same model non-SVD 50) healthy older adults 203). In further study, damage mediating subgroup 101) underwent diffusion tensor imaging (DTI). Results: Reduced was associated depression SVD, but not by or cognition; very similar were found replication cohort. contrast, group adult showed direct relationship between depression. The DTI that fractional anisotropy, marker related SVD. Conclusion: These suggest without an important causal whereas stroke, other factors subtype have role. White detected one mediates