Cardiometabolic health of children conceived by assisted reproductive technologies.

摘要: The cardiometabolic health of children conceived by assisted reproductive technologies (ART) compared with without medical assistance is unclear. Although the majority published studies evaluating height, weight, and body mass index have not found differences method conception, some indicated in adiposity more direct measures such as skinfolds dual X-ray absorptiometry. Far fewer investigated other characteristics, blood pressure lipid glucose metabolism. Of these studies, indications increased recent findings vascular dysfunction among ART warrant further investigation. Epigenetic may be global mechanism at work, resulting from different aspects treatment, ovarian stimulation, in vitro culture, manipulation sperm, considerations. Fetal growth placental development serve mediators effects. Future should consider recruiting sufficient numbers non-ART multiples collect information on indicators parents. Despite advantages sibling cohorts developmental origins research, its feasibility utility for investigating remains debatable.