Release of soluble ICAM-1 from human lung fibroblasts, aortic smooth muscle cells, dermal microvascular endothelial cells, bronchial epithelial cells, and keratinocytes.
作者： Kam H. Leung
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摘要: Abstract We determined effects of IL-1α, TNFα and IFNγ on sICAM-1 release in culture media from human aortic smooth muscle cells (AOSMC), dermal microvascular endothelial (DMEC), keratinocytes (KC), bronchial epithelial (BEC) lung fibroblasts (LF) as by ELISA. Under basal conditions cultures for 20 h, low concentrations were only detected the two (DMEC BEC) these cell types. stimulated cells. more shedding AOSMC, BEC KC than IL-1α or TNFα. enhanced DEMC LF. acted synergistically to enhance The levels pathophysiological may influence leukocyte-vascular interactions block leukocyte transmigration tissue injury sites a negative feedback mechanism.
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