Prognostic Significance for Stroke of a Morning Pressor Surge and a Nocturnal Blood Pressure Decline: The Ohasama Study

摘要: There is continuing controversy over whether the pattern of circadian blood pressure (BP) variation that includes a nocturnal decline in BP and morning pressor surge has prognostic significance for stroke risk. In this study, we followed incidence 1430 subjects aged > or =40 years Ohasama, Japan, an average 10.4 years. The association between risk was analyzed with Cox proportional hazards model after adjustment possible confounding factors. no significant total (percentage from diurnal level) surge. cerebral infarction significantly higher =10% (P=0.04). not associated infarction. On other hand, increased hemorrhage observed large (> =25 mm Hg; P=0.04). Intracerebral also more frequently extreme dippers (those =20% BP) than 10% to 19% decline; P=0.02). A disturbed infarction, whereas BP, which are analogous increase both hemorrhage.