Labetalol blunts morning pressor surge in systolic hypertension.

摘要: Twenty-four-hour ambulatory blood pressure, including the acceleration phase, and left ventricular mass were evaluated in 16 patients with isolated systolic hypertension (standing pressure greater than or equal to 160 mm Hg less 95 diastolic). After a 4-week, single-blind, placebo period, each patient underwent 24-hour monitoring echocardiography. Labetalol therapy was then initiated at 100 mg twice day single-blind manner increased weekly by until control obtained maximum dosage of 400 reached. Blood achieved mean daily dose 363 +/- 46 labetalol. Measurements repeated end an 8-week maintenance phase. significantly reduced from 154 8 (mean SEM) baseline 142 6 (p 0.01) controlled early morning surge pressure. Minor reductions diastolic heart rate statistically but not clinically significant. Left changed. monotherapy provides effective hypertension.