The X-ray structure of Salmonella typhimurium uridine nucleoside phosphorylase complexed with 2,2'-anhydrouridine, phosphate and potassium ions at 1.86 A resolution.
作者： Alexander A. Lashkov , Nadezhda E. Zhukhlistova , Azat H. Gabdoulkhakov , Alexander A. Shtil , Roman G. Efremov
DOI: 10.1107/S0907444909044175
关键词:
摘要: Uridine nucleoside phosphorylase is an important drug target for the development of anti-infective and antitumour agents. The X-ray crystal structure Salmonella typhimurium uridine (StUPh) complexed with its inhibitor 2,2′-anhydrouridine, phosphate potassium ions has been solved refined at 1.86 A resolution (Rcryst = 17.6%, Rfree 20.6%). complex human I (HUPhI) 2,2′-anhydrouridine was modelled using a computational approach. model allowed identification atomic groups in that might improve interaction future inhibitors StUPh HUPhI.
rcsb.org参考文章(39)
M H el Kouni, F N Naguib, J G Niedzwicki, M H Iltzsch, S Cha, Uridine phosphorylase from Schistosoma mansoni. Journal of Biological Chemistry. ,vol. 263, pp. 6081- 6086 ,(1988) , 10.1016/S0021-9258(18)68752-6
G Gosselin, T Ueda, S M Cha, B A Otter, S H Chu, Y F Shealy, M H el Kouni, J L Imbach, F N Naguib, Effect of the N-glycosidic bond conformation and modifications in the pentose moiety on the binding of nucleoside ligands to uridine phosphorylase. Molecular Pharmacology. ,vol. 34, pp. 104- 110 ,(1988)
Nancy Kemeny, Role of chemotherapy in the treatment of colorectal carcinoma. Seminars in Surgical Oncology. ,vol. 3, pp. 190- 214 ,(1987) , 10.1002/SSU.2980030312
Frances C. Bernstein, Thomas F. Koetzle, Graheme J.B. Williams, Edgar F. Meyer, Michael D. Brice, John R. Rodgers, Olga Kennard, Takehiko Shimanouchi, Mitsuo Tasumi, The Protein Data Bank: a computer-based archival file for macromolecular structures. Journal of Molecular Biology. ,vol. 112, pp. 535- 542 ,(1977) , 10.1016/S0022-2836(77)80200-3
Joachim H. Gieringer, Andrea F. Wenz, Heinz-M. Just, Franz D. Daschner, Effect of 5-fluorouracil, mitoxantrone, methotrexate, and vincristine on the antibacterial activity of ceftriaxone, ceftazidime, cefotiam, piperacillin, and netilmicin. Chemotherapy. ,vol. 32, pp. 418- 424 ,(1986) , 10.1159/000238445
E.Yu. Morgunova, A.M. Mikhailov, A.N. Popov, E.V. Blagova, E.A. Smirnova, B.K. Vainshtein, Ch. Mao, Sh.R. Armstrong, S.E. Ealick, A.A. Komissarov, E.V. Linkova, A.A. Burlakova, A.S. Mironov, V.G. Debabov, Atomic structure at 2.5 Å resolution of uridine phosphorylase from E. coli as refined in the monoclinic crystal lattice FEBS Letters. ,vol. 367, pp. 183- 187 ,(1995) , 10.1016/0014-5793(95)00489-V
John G. Niedzwicki, Mahmoud H. El Kouni, Shih Hsi Chu, Sungman Cha, Structure-activity relationship of ligands of the pyrimidine nucleoside phosphorylases Biochemical Pharmacology. ,vol. 32, pp. 399- 415 ,(1983) , 10.1016/0006-2952(83)90517-8
R. A. Laskowski, M. W. MacArthur, D. S. Moss, J. M. Thornton, PROCHECK: a program to check the stereochemical quality of protein structures Journal of Applied Crystallography. ,vol. 26, pp. 283- 291 ,(1993) , 10.1107/S0021889892009944
Maria Zolotukhina, Irina Ovcharova, Svetlana Eremina, Liubov Errais Lopes, Alexander S Mironov, None, Comparison of the structure and regulation of the udp gene of Vibrio cholerae, Yersinia pseudotuberculosis, Salmonella typhimurium, and Escherichia coli. Research in Microbiology. ,vol. 154, pp. 510- 520 ,(2003) , 10.1016/S0923-2508(03)00125-6
Francesco Balestri, Catia Barsotti, Ludovico Lutzemberger, Marcella Camici, Piero Luigi Ipata, Key role of uridine kinase and uridine phosphorylase in the homeostatic regulation of purine and pyrimidine salvage in brain. Neurochemistry International. ,vol. 51, pp. 517- 523 ,(2007) , 10.1016/J.NEUINT.2007.06.007