Incidence of dementia and association with APOE genotype in older Cubans
作者： Juan J. Llibre Rodríguez , Adolfo Valhuerdi Cepero , Isis Y. Sanchez Gil , Ana M. López Medina , Juan C. Llibre-Guerra
DOI: 10.1590/S1980-57642014DN84000009
关键词:
摘要: Objective: In an admixed population of older Cubans, the incidence and association APOE socio demographic risk factors with dementia was estimated. Methods: A single-phase survey (baseline) all over 65-year-olds residing in seven catchment areas Cuba (n=2944) conducted between 2003 2007. Dementia diagnosis established according to DSM-IV 10/66 criteria. genotype determined 2520 participants. An wave 4.5 years after cohort inception order estimate associations sociodemographic e4 genotype. Results: The rate DSM IV 9.0 per 1000 person-years (95% CI 7.2-11.3) 20.5 CI, 17.6-23.5). Older age, a family history were independent for incident dementia. associated cross-sectionally prevalence, but effect on attenuated, only apparent among those youngest age group. Conclusion: Cuban is relatively high similar levels reported Europe North-America. study showed that relationship stronger younger-old than older-old this change must be taken into account models
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