Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways

摘要: Progesterone receptor (PR) is a member of the nuclear family ligand-dependent transcription activators and expressed as two different sized proteins from single gene; PR-A PR-B. The PR isoforms are identical in their DNA binding domains (DBD) C-terminal ligand (LBD), differing only N-terminal domain that truncated PR-A. also contains autonomous activation (AD), AF-2 C-terminus constitutive AF-1 N-terminus. highly conserved p160 coactivators interacts with mediates activity has been well characterized. By contrast not little known about coactivators. functionally important it required for full responsible distinct activities isoforms, cell promoter specific functions PR. This paper describes our efforts to identify interacting coregulatory proteins. We summarize work on role jun dimerization protein-2 (JDP-2) an coactivator JDP-2, initially defined repressor other bZIP factors, potent selective coactivator. JDP-2 lacks intrinsic through association DBD, we propose potentiates by recruiting independent pathways. discovered SH3 interaction motif N-terminus Src tyrosine kinases signaling molecules. rapid progesterone Src/MAP K pathways defines molecular mechanism some non-genomic actions progesterone.