Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53

摘要: Dickkopf-1 (Dkk-1), a secreted glycoprotein, has been found to be necessary and sufficient for inducing amphibian head formation. Interestingly, the mechanism by which Dkk-1 does this is ability of antagonize Wnt signaling pathway. Wnt, itself proto-oncoprotein, can promote cell proliferation transformation when mutated or overexpressed, leading tumor p53 suppressor loss function accelerates mammary tumorigenesis Wnt. In study, we that induced wild-type but not mutant p53(R249S). addition, DNA damage upregulates in lines harbor an endogenous gene are p53-null gene. We also potential responsive element located approximately 2100 nucleotides upstream transcription start site show binds specifically both vitro vivo. Furthermore, have established several derived from H1299 lung carcinoma U118 glioma cells inducibly express under tetracycline-regulated promoter. no effect on transformed Taken together, these results suggest may mediate suppression antagonizing