CELLULAR TRAFFICKING AND PROCESSING OF THE INSULIN RECEPTOR
作者： Victoria P. Knutson
DOI: 10.1096/FASEBJ.5.8.2022311
关键词:
摘要: The insulin receptor is a dynamic cellular macromolecule that moves through various compartments of the cell throughout its lifetime. This review addresses processes involved in synthetic assembly receptor; interaction with protein; receptor-mediated endocytosis insulin; and role tyrosine serine phosphorylation both recycling. discussion concluded by examining data available on intracellular inactivation degradation protein. Emphasis given to regulation imposed at each these steps processing, how use pharmacologic physiologic perturbants has afforded experimental insights into mechanisms utilizes modulating expression functioning receptor.
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