Internalization of Insulin: Structures Involved and Significance
作者： Barry I. Posner , Masood N. Kahn , John J. M. Bergeron
DOI: 10.1007/978-1-4757-1850-8_10
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摘要: The binding of insulin to its receptor is followed by aggregation hormone-receptor complexes and their internalization into the cell. Internalized hormone concentrated in Golgi-enriched not lysosomal endocytotic structures which, rat liver, contain lipoprotein particles can be resolved centrifugation techniques three different entities. Recent work has shown that bulk from biochemically defined (i.e., galactosyltransferase-containing) Golgi elements. endosomal apparatus or endosomes appear function as a sorting center wherein internalized are dissociated prior directing lysosomes back cell surface for reutilization. Endosomes heterogeneous functions might subserved structures. Since an stimulable kinase activity identified certain aspects action initiated herein.
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