Cerebral blood flow response to the tissue temperature in tumour and brain tissues.

摘要: The response of regional-cerebral blood flow (rCBF) to change in the tissue temperature was studied using normal and tumour-bearing monkeys. local brain selectively heated by external microwave irradiation, while body kept hypothermic (30.1 +/- 0.1 degrees C, mean standard error) immersion a cold water bath. rCBF and/or tumour tissues sequentially measured inhalation hydrogen clearance method. In animal study (n = 7), changed temperatures over range 29.4-40.7 C with constant rate 15.2% per degree Celsius change. Similarly, animals 7) proportionately 28.4-42.5 27.6-41.8 tissue. 6.5% for tumour, which significantly smaller than that (13.5%) (P less 0.01). These results indicated can be controlled defined application selective heating ranging from shallow hypothermia modest hyperthermia. Vascular may play significant role heat treatment.