Interaction of heat with radiation and chemotherapy.

摘要: Abstract In using hyperthermia in the clinic, thermal dosimetry is essential and discussed terms of equating time-temperature relationships for an isoeffect to equivalent time at a reference temperature, 43° example. applying time-temperature-equivalence, sequence between heat radiation two treatments, dose rate, linear energy transfer, physiological parameters must be considered. Furthermore, tolerance observed both killing radiosensitization, especially doses 400 rads or greater, may considered as modifier. When combined with drugs, most factors mentioned above are probably important need careful evaluation, including applicability calculating temperature. Examples given delayed sensitization after depletion intracellular polyamines partially overcoming resistance 1,3-bis-2-chloroethylnitrosourea order illustrate importance understanding effects on formation reactive drug intermediates, permeability drugs into cells, damage target molecules.