Importance of thermotolerance for radiothermotherapy as assessed using two human melanoma cell lines.

摘要: In the combined treatment of tumors by means hyperthermia and ionizing radiation, sequence, interval between two treatments, frequency heat treatments are still open questions. this discussion development thermotolerance plays an important role. It has frequently been observed that cells become more thermoresistant during prolonged heating at relatively low temperatures or fractionated application (review see: Henle Dethlefsen 1978; Dewey et al. 1971; van Beuningen Streffer 1985; Field Law 1979; Palzer Heidelberg 1981; Anderson 1982). The phenomenon could be very for clinical use if it also occurred in connection with radiosensitization human tumors. Up to now most studies on have performed alone only a few experiments done combination radiation (Henle Freeman Nielsen Overgaard Stewart Denekamp 1980; 1982; 1984; Holohan Havemann 1983a; 1983; Jorritsma Rijn Jung 1986; 1984). results conflicting. Furthermore, is difficult prove existence vivo. aim presented show how can interact especially after modalities.