Bioinformatics and Experimental Design for Biomarker Discovery
作者： Marc R. Wilkins , Sybille M. N. Hunt
DOI: 10.1007/978-1-59745-432-2_8
关键词:
摘要: Proteomics is supremely well suited to the discovery of biomarkers in human body fluids. However, diversity population and multistep nature most proteomic techniques require great care be taken experimental design data analysis. This chapter out-lines strategies for biomarker discovery, using 2D polyacrylamide gel electrophoresis or other technologies, explores issues analytical biological variation, quality, statistical Particular attention given issue how this can influence outcomes efforts.
springer.com
sci-hub.st 参考文章(72)
T. Urbanowska, S. Mangialaio, C. Hartmann, F. Legay, Development of protein microarray technology to monitor biomarkers of rheumatoid arthritis disease. Cell Biology and Toxicology. ,vol. 19, pp. 189- 202 ,(2003) , 10.1023/A:1024729526867
Fabio Dall'Olio, Mariella Chiricolo, Sialyltransferases in cancer. Glycoconjugate Journal. ,vol. 18, pp. 841- 850 ,(2001) , 10.1023/A:1022288022969
David F. Ransohoff, Bias as a threat to the validity of cancer molecular-marker research Nature Reviews Cancer. ,vol. 5, pp. 142- 149 ,(2005) , 10.1038/NRC1550
PH O'Farrell, High resolution two-dimensional electrophoresis of proteins. Journal of Biological Chemistry. ,vol. 250, pp. 4007- 4021 ,(1975) , 10.1016/S0021-9258(19)41496-8
Sreelatha Meleth, Jessy Deshane, Helen Kim, The case for well-conducted experiments to validate statistical protocols for 2D gels: different pre-processing = different lists of significant proteins. BMC Biotechnology. ,vol. 5, pp. 7- 7 ,(2005) , 10.1186/1472-6750-5-7
Daniel J. Sargent, Barbara A. Conley, Carmen Allegra, Laurence Collette, Clinical Trial Designs for Predictive Marker Validation in Cancer Treatment Trials Journal of Clinical Oncology. ,vol. 23, pp. 2020- 2027 ,(2005) , 10.1200/JCO.2005.01.112
Mark P. Molloy, Erin E. Brzezinski, Junqi Hang, Michael T. McDowell, Ruth A. VanBogelen, Overcoming technical variation and biological variation in quantitative proteomics Proteomics. ,vol. 3, pp. 1912- 1919 ,(2003) , 10.1002/PMIC.200300534
Xianquan Zhan, Dominic M. Desiderio, Differences in the spatial and quantitative reproducibility between two second-dimensional gel electrophoresis systems Electrophoresis. ,vol. 24, pp. 1834- 1846 ,(2003) , 10.1002/ELPS.200305389
Emilie Lukášová, Zdeněk Kořistek, Martin Falk, Stanislav Kozubek, Sergei Grigoryev, Michal Kozubek, Vladan Ondřej, Iva Kroupová, Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities Journal of Leukocyte Biology. ,vol. 77, pp. 100- 111 ,(2005) , 10.1189/JLB.0704388
Marc R. Wilkins, Elisabeth Gasteiger, Andrew A. Gooley, Ben R. Herbert, Mark P. Molloy, Pierre-Alain Binz, Keli Ou, Jean-Charles Sanchez, Amos Bairoch, Keith L. Williams, Denis F. Hochstrasser, High-throughput mass spectrometric discovery of protein post-translational modifications. Journal of Molecular Biology. ,vol. 289, pp. 645- 657 ,(1999) , 10.1006/JMBI.1999.2794