Bias as a threat to the validity of cancer molecular-marker research

作者: David F. Ransohoff

DOI: 10.1038/NRC1550

关键词: Molecular markerPsychologyComputational biologyOmicsCancerInterpretation (philosophy)Cancer researchOncology

摘要: Claims that molecular markers can accurately diagnose cancer have recently been disputed; some prominent results not reproduced and bias has proposed to explain the original observations. As new '-omics' fields are explored assess for cancer, will increasingly be recognized as most important 'threat validity' must addressed in design, conduct interpretation of such research.

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