The inflammatory response and tissue damage. The example of renal scars following acute renal infection.

摘要: Most clinical and experimental evidence suggests that renal scarring occurs following urinary tract infections in those patients with an abnormality of the or kidney function. Experimentally, bacterial multiplication within only presence obstruction, leading rapidly to acute exudative pyelonephritis invariably scars weeks. Various manipulations load and/or inflammatory response during have demonstrated processes, not component pyelonephritis, are responsible for permanent tissue damage. Polymorphonuclear leucocytes (PMNLs) infiltrating appear release metabolites toxic parenchyma. Indeed, both prevention PMNL influx into tissue, by means colchicine cyclophosphamide, inactivation some their metabolites, dapsone, led damage scars. However, most potent protective activity was observed early antibiotic treatment, which stopped prevented PMNLs, thus preventing scar formation. Similar observations been made children pyelonephritic episodes, whom aggressive treatment subsequent scars, while delayed did not.