Emerging Evidence concerning the Role of Sirtuins in Sepsis
作者： Lulan Li , Zhongqing Chen , Weijun Fu , Shumin Cai , Zhenhua Zeng
DOI: 10.1155/2018/5489571
关键词:
摘要: Sepsis, a dysregulated host response to infection, is major public health concern. Though experimental and clinical studies relating sepsis are increasing, the mechanism of not completely understood. To date, numerous have shown that sirtuins (silent mating type information regulation 2 homolog), which belong class III histone deacetylases, may varied, or even opposite, effect in pathogenesis sepsis. Notably, downstream mechanisms fully The sirtuin family consists 1–7; among them, 1 (SIRT1) most studied one, during development Furthermore, other members also confirmed be involved inflammatory metabolic signaling following In addition, interact with each form precise regulatory different phases Therefore, this review, by accumulating data from PubMed, we intend explain role sepsis, hope will pave way for further study potential future applications sirtuins.
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