Epidermal Growth Factor and Epidermal Growth Factor Receptor: The Yin and Yang in the Treatment of Cutaneous Wounds and Cancer.
作者： Richard J. Bodnar
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摘要: Significance: Epidermal growth factor (EGF) and EGF receptor (EGFR) play an essential role in wound healing through stimulating epidermal dermal regeneration. The development of new therapies for enhancing has included the use EGF. In addition, EGFR inhibitors (EGFRis) have become a therapeutic option treatment cancer. Thus, targeting EGF/EGFR are useful both cutaneous wounds Recent Advances: Identification as regulator normal pathological cell function allowed EGFRis cancer topical administration to enhance healing. Critical Issues: EGFRi emerged metastatic cancers. These drugs induce dermatological toxicity, papulopustular rash that is pruritic painful; chronic may negatively impact Currently, there no standard therapy alleviate side effects caused by except r...
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