Cutaneous side-effects of EGFR inhibitors and their management.

摘要: Epidermal growth factor receptor (EGFR) inhibitors are an increasingly important treatment option for metastasized cancer in patients. In addition to the pivotal role of EGFR development and progression malignant tumors, is also proliferation differentiation human epidermis hair follicles. As a consequence, cutaneous side-effects frequently observed during therapy with inhibitors. During first few weeks treatment, acneiform eruptions earliest common side-effect. Xerosis fissures complications appearing later phases. Paronychia alterations less generally seen after longer period treatment. We present overview various associated inhibition discuss their respective therapeutic options.