A review of the treatment options for skin rash induced by EGFR-targeted therapies: Evidence from randomized clinical trials and a meta-analysis.

摘要: Background: Agents targeting the epidermal growth factor receptor (EGFR) are amongst most extensively used of targeted agents in therapy some common solid tumors. Although they avoid many classic side effects associated with cytotoxic chemotherapy, unpleasant cutaneous toxicities which can affect treatment compliance and impinge on patient quality life. To date, despite a plethora consensus recommendations, expert opinions reviews, there is paucity evidence-based guidance for management skin rash that occurs patients receiving EGFR-targeted therapies. Methods: A literature search was conducted as first step towards investigating not only an approach to rash, but also view designing future randomized trials. Results: The identified seven trials meta-analysis using data from four these involving oral antibiotics. suggests prophylactic antibiotics might reduce relative risk severe by 42–77%. Vitamin K cream having potential role agent induced rash. Conclusion: This review clearly identify need further studies this setting. results ongoing topical application vitamin plus or minus doxycycline employing versus reactive strategies eagerly awaited.