Cutaneous lesions due to inhibition of epidermal growth factor receptor

摘要: Malignant tumors are increasingly being treated with therapeutic agents having molecular mechanisms of action (so-called biologics). These include for the blockade epidermal growth factor receptor (EGFR). The adverse drug reaction profile associated EGFR inhibitors is dominated by cutaneous lesions. Most common acneiform skin reactions followed xerosis, eczema and changes to hair nails. vary greatly between individuals may be relatively insignificant. However, they also prevent continuation therapy. During use inhibitors, a correlation was observed severity effectiveness agent, finding potentially useful individual dose adjustment.