NON‐INVASIVE MYOCARDIAL IRON ASSESSMENT IN THALASSAEMIC PATIENTS
作者： N. Papanikolaou , A. Ghiatas , A. Kattamis , C. Ladis , N. Kritikos
DOI: 10.1034/J.1600-0455.2000.041004348.X
关键词:
摘要: Purpose: To compare T2 relaxometry and magnetization transfer ratio (MTR) measurements of myocardial tissue in normal volunteers thalassaemic patients for assessment the iron levels. Material Methods: All examinations were done on a 1 T MR system using multi-echo spin-echo sequence with 8 echoes gradient echo MTR measurements. Diastolic cardiac triggering was used both sequences. Ten 10 subjects included study. correlated serum ferritin levels. Results: Regression analysis between demonstrated reversed linear relationship, (r=−0.932, p<0.05) (r=−0.824, p<0.05), respectively. Mean relaxation time mean (57.95±4.9 ms 43.70±3.3%) significantly higher than that (38.8±6.2 26.40±6.1%) (p<0.01), respectively. Conclusion: can be to complement non-invasive assessment.
blackwell-synergy.com参考文章(11)
Frank Q. Ye, W. R. Wayne Martin, Peter S. Allen, Estimation of brain ironin vivo by means of the interecho time dependence of image contrast Magnetic Resonance in Medicine. ,vol. 36, pp. 153- 158 ,(1996) , 10.1002/MRM.1910360124
Ruth M. Dixon, Peter Styles, An assessment of spin-echo rotating-frame imaging for spatially localized determination of short T2 relaxation times in vivo Magnetic Resonance in Medicine. ,vol. 29, pp. 110- 112 ,(1993) , 10.1002/MRM.1910290119
Paul A. Bottomley, Thomas H. Foster, Raymond E. Argersinger, Leah M. Pfeifer, A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: Dependence on tissue type, NMR frequency, temperature, species, excision, and age Medical Physics. ,vol. 11, pp. 425- 448 ,(1984) , 10.1118/1.595535
S D Wolff, R S Balaban, Magnetization transfer imaging: practical aspects and clinical applications. Radiology. ,vol. 192, pp. 593- 599 ,(1994) , 10.1148/RADIOLOGY.192.3.8058919
V Dousset, R I Grossman, K N Ramer, M D Schnall, L H Young, F Gonzalez-Scarano, E Lavi, J A Cohen, Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology. ,vol. 182, pp. 483- 491 ,(1992) , 10.1148/RADIOLOGY.182.2.1732968
D D Stark, M E Moseley, B R Bacon, A A Moss, H I Goldberg, N M Bass, T L James, Magnetic resonance imaging and spectroscopy of hepatic iron overload. Radiology. ,vol. 154, pp. 137- 142 ,(1985) , 10.1148/RADIOLOGY.154.1.3964933
Olympia G. Papakonstantinou, Thomas G. Maris, Voula Kostaridou, Athanassios D. Gouliamos, Gregoris K. Koutoulas, Angelos E. Kalovidouris, George B. Papavassiliou, George Kordas, Christos Kattamis, Lambros J. Vlahos, Constantinos G. Papavassiliou, Assessment of liver iron overload by T2-Quantitative magnetic resonance imaging: Correlation of T2-QMRI measurements with serum ferritin concentration and histologic grading of siderosis Magnetic Resonance Imaging. ,vol. 13, pp. 967- 977 ,(1995) , 10.1016/0730-725X(95)00041-E
Warren D. Foltz, Jeffery A. Stainsby, Graham A. Wright, T2 Accuracy on a whole-body imager Magnetic Resonance in Medicine. ,vol. 38, pp. 759- 768 ,(1997) , 10.1002/MRM.1910380512
J M Gomori, G Horev, H Tamary, J Zandback, L Kornreich, R Zaizov, E Freud, O Krief, J Ben-Meir, H Rotem, M Kuspet, P Rosen, E L Rachmilewitz, R Gorodetsky, Hepatic iron overload: quantitative MR imaging. Radiology. ,vol. 179, pp. 367- 369 ,(1991) , 10.1148/RADIOLOGY.179.2.2014276
George Bartzokis, Manickam Aravagiri, William H. Oldendorf, Jim Mintz, Stephen R. Marder, Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores Magnetic Resonance in Medicine. ,vol. 29, pp. 459- 464 ,(1993) , 10.1002/MRM.1910290406