Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections

摘要: This invention concerns the use of compounds formula (I) N-oxides, pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n 0, 1, 2, 3 4; R?1 R2? are each independently selected from hydrogen, hydroxy, C?1-12?alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- di(C1-12alkyl)amino, di(C1-12alkyl)aminocarbonyl aforementioned C1-12alkyl groups may optionally individually be substituted; taken together form pyrrolidinyl, piperidinyl, morpholinyl, azido di(C?1-12?alkyl)aminoC1-4alkylidene; R?3? C?1-6?alkylcarbonyl, substituted C1-6alkyl; R?4? halo, C?1-6?alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, trihalomethyl trihalomethyloxy; L -X-R?5? -X-Alk-R6; R?5 R6? indanyl, indolyl phenyl; said phenyl X -NR3-, -NH-NH-, -N=N-, -O-, -S-, -S(=O)- -S(=O)?2?-; aryl Het an aliphatic aromatic heterocyclic radical; for manufacture a medicine treatment subjects suffering HIV (Human Immunodeficiency Virus) infection. It further relates to new being subgroup (I), their preparation pharmaceutical compositions comprising them.