Disubstituted triazine dimers for treatment and/or prevention of infectious diseases
作者： Pieter Van Der Veken , Koen Augustyns , Venkatraj Muthusamy , Louis Maes , Jurgen Joossens
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摘要: The present invention relates to novel compounds (I) containing two disubstituted triazine rings covalently linked by an organic linker, thereby creating dimers. These show activity against the causative infective agents of infectious diseases such as African trypanosomiasis, Chagas disease, Leishmaniasis, Malaria and HIV. further prevention and/or treatment these diseases.
lens.org参考文章(17)
William K. Hagmann, Malcolm Maccoss, Charles G. Caldwell, Shrenik K. Shah, Karla L. Furman, Kothandaraman Shankaran, Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases Official Gazette of the United States Patent and Trademark Office Patents. ,(1996)
Kurt Hertogs, Eva Bettens, Frederik Frans Desiré Daeyaert, Lucien Maria Henricus Koymans, Paulus Joannes Lewi, Hendrik Maarten Vinkers, Jonge Marc René De, Paul Adriaan Jan Di Janssen, Elisabeth Thérese Jeanne Pasquier, Jan Heeres, Jerôme Emile Georges Guillemont, Hiv replication inhibiting pyrimidines and triazines ,(2004)
Paul Stoffels, Jens Marcel Van Roey, Marie-Pierre T.M. M. G. De Bethune, Microbicidal pyrimidine or triazine for preventing sexual hiv transmission ,(2003)
Brigitte Grouix, Jean-Simon Duceppe, Shaun D. Abbott, Jean-François Bienvenu, Nancie Moreau, Lyne Gagnon, Boulos Zacharie, Daniel Fortin, Nicole Wilb, Karine Houde, Alan D. Cameron, Christopher Penney, Abdallah Ezzitouni, Triazine dimers for the treatment of autoimmune diseases ,(2004)
Robert W. Kavash, Donald William Ludovici, Corte Bart De, Lucien Maria Henricus Koymans, Chih Yung Ho, Frederik Frans Desire Daeyaert, Michael Joseph Kukla, Jan Heeres, Jonge Marc Rene De, Paul Adriaan Jan Janssen, Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections ,(1999)
James Marvin Veal, Karey Elizabeth Lackey, Stephen Vernon Frye, Robert Neil Hunter, Philip Anthony Harris, Stephen Thomas Davis, Duncan Herrick Walker, Scott Howard Dickerson, Michael Joseph Luzzio, Lee Frederick Kuyper, Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors ,(1998)
William Trager, James B. Jensen, Continuous culture of Plasmodium falciparum: its impact on malaria research International Journal for Parasitology. ,vol. 27, pp. 989- 1006 ,(1997) , 10.1016/S0020-7519(97)00080-5
Muthusamy Venkatraj, Kevin K. Ariën, Jan Heeres, Jurgen Joossens, Jonas Messagie, Johan Michiels, Pieter Van der Veken, Guido Vanham, Paul J. Lewi, Koen Augustyns, Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents Bioorganic & Medicinal Chemistry Letters. ,vol. 22, pp. 7174- 7178 ,(2012) , 10.1016/J.BMCL.2012.09.066
K. H. Mayer, C. L. Karp, P. G. Auwaerter, K. H. Mayer, Coinfection with HIV and Tropical Infectious Diseases. I. Protozoal Pathogens Clinical Infectious Diseases. ,vol. 45, pp. 1208- 1213 ,(2007) , 10.1086/522181
Donald W. Ludovici, Robert W. Kavash, Michael J. Kukla, Chih Y. Ho, Hong Ye, Bart L. De Corte, Koen Andries, Marie-Pierre de Béthune, Hilde Azijn, Rudi Pauwels, Henry E.L. Moereels, Jan Heeres, Lucien M.H. Koymans, Marc R. de Jonge, Koen J.A. Van Aken, Frederik F.D. Daeyaert, Paul J. Lewi, Kalyan Das, Edward Arnold, Paul A.J. Janssen, Evolution of Anti-HIV Drug CandidatesPart 2: Diaryltriazine (DATA) Analogues Bioorganic & Medicinal Chemistry Letters. ,vol. 11, pp. 2229- 2234 ,(2001) , 10.1016/S0960-894X(01)00411-5