Methods of treating neurological disorders

作者: Alon Friedman , Daniela Kaufer , Luisa Cacheaux

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摘要: The present invention provides methods of treating epilepsy and other neurological disorders. generally involve administering to an individual in need thereof effective amount agent that blocks a transforming growth factor-beta pathway

参考文章(12)
Pieter Jaap Gaillard, Boer Albertus Gerrit De, Arjen Brink, Differentially expressed nucleic acids in the blood-brain barrier under inflammatory conditions ,(2004)
Ingo Kleiter, Stefan Limmer, Hans-Peter Vornlocher, Rainer Apfel, Gerhard Giegerich, Andreas Steinbrecher, Roland Kreutzer, Markus Horn, Smad7 inhibitors for the treatment of cns diseases ,(2002)
Hantamalala Ralay Ranaivo, Mark S. Wainwright, Albumin activates astrocytes and microglia through mitogen-activated protein kinase pathways. Brain Research. ,vol. 1313, pp. 222- 231 ,(2010) , 10.1016/J.BRAINRES.2009.11.063
Manav Korpal, Yibin Kang, Targeting the transforming growth factor-β signalling pathway in metastatic cancer European Journal of Cancer. ,vol. 46, pp. 1232- 1240 ,(2010) , 10.1016/J.EJCA.2010.02.040
S. Ivens, D. Kaufer, L. P Flores, I. Bechmann, D. Zumsteg, O. Tomkins, E. Seiffert, U. Heinemann, A. Friedman, TGF-β receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis Brain. ,vol. 130, pp. 535- 547 ,(2007) , 10.1093/BRAIN/AWL317
Richard J. Perrin, Anne M. Fagan, David M. Holtzman, Multimodal techniques for diagnosis and prognosis of Alzheimer's disease Nature. ,vol. 461, pp. 916- 922 ,(2009) , 10.1038/NATURE08538
James C. Vickers, A vaccine against Alzheimer's disease: developments to date. Drugs & Aging. ,vol. 19, pp. 487- 494 ,(2002) , 10.2165/00002512-200219070-00002
Robert L. Yauch, David A. Eberhard, John D. Haley, Graeme Griffin, Lukas A. Amler, Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors ,(2006)
Shaoping Xie, Maria B. Sukkar, Razao Issa, Ute Oltmanns, Andrew G. Nicholson, Kian Fan Chung, Regulation of TGF-β1-induced connective tissue growth factor expression in airway smooth muscle cells American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 288, ,(2005) , 10.1152/AJPLUNG.00156.2004