RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA)
作者： Leonid Beigelman , James McSwiggen
DOI:
关键词:
摘要: This invention relates to compounds, compositions, and methods useful for modulating tumor necrosis factor and/or receptor gene expression using short interfering nucleic acid (siNA) molecules. also the activity of other genes involved in pathways by RNA interference (RNAi) small In particular, instant features molecules, such as (siNA), (siRNA), double-stranded (dsRNA), micro-RNA (miRNA), hairpin (shRNA) molecules used modulate genes, (TNF TNF receptor).
google.ca 参考文章(108)
David Parsons, Maria Fuller, Maria Limberis, Don Anson, Respiratory delivery for gene therapy and lentiviral delivery particle ,(2002)
Nassim Usman, Alex Karpeisky, Jasenka Matulic-Adamic, Leonid Beigelman, Francine Wincott, Non-nucleotide containing nucleic acid ,(2000)
Ian Maclachlan, Lipid-based formulations ,(2002)
Stanley T. Crooke, Oligoribonucleotides for cleaving RNA ,(1996)
James McSwiggen, RNA interference mediated treatment of Alzheimer's disease using short interfering RNA ,(2002)
Bruce Alan Sullenger, Thomas Robert Cech, Localization of a therapeutic agent in a cell in vitro ,(1994)
Jeffrey M. Bockman, Shaji T. George, Andy Shih, Ribozyme amplified diagnostics ,(1993)
C. Frank Bennett, Andrew T. Watt, Antisense modulation of tumor necrosis factor receptor 2 expression ,(2002)
Brian Dr Sproat, Giovanni Dr Paolella, Angus Dr Lamond, Synthetic catalytic oligonucleotide structures ,(1992)