Association of Interleukin 13 +2044G/A Polymorphism with Bronchial Asthma Development, Severity and Immunoglobulin E levels in an Egyptian Population

摘要: Background: Asthma is a chronic, inflammatory disease of the respiratory tract, which characterized by bronchial hyperreactivity and obstruction in many cells cellular elements play role. Interleukin 13 (IL-13) type 2 helper T (Th2) cytokine that has been shown to be pivotal induction allergic inflammation airways. Moreover, Several IL-13 genetic polymorphisms have linked with susceptibility asthma. Aim: The aim this study was evaluate association + 2044G/A polymorphism asthma development, severity total serum immunoglobulin E (IgE) levels Egyptian patients Subjects methods: This included 50 asthmatic 30 controls. Restriction Fragment Length Polymorphism (RFLP) PCR used for analysis studied polymorphism. Also, analyzed IgE enzyme-linked immunosorbent assay (ELISA). Results: frequency A allele significantly higher as compared control subjects. On contrary, G less frequent In addition more severe on other hand patients. presence associated whether homozygous or heterozygous state. Conclusions: results showed +2044 risk factor There significant between asthma, however addition, levels.