Simple organ failure count versus CANONIC grading system for predicting mortality in acute‐on‐chronic liver failure

摘要: Background and Aim This study assessed the utility of a simple organ failure count (SOFC) in predicting in-hospital mortality patients with acute-on-chronic liver (ACLF) compared Chronic Liver Failure Acute-on-Chronic Cirrhosis (CANONIC) ACLF grading system. Methods Consecutive were included prospectively from 2012 to 2013. The diagnosis was based on Asian-Pacific Association for Study (APASL) criteria except inclusion non-hepatic insults as acute events. Organ failures defined per Failure–Sequential Assessment system. SOFC calculated number 0 6. In-hospital recorded. Results Majority (92[87%]) 106 males, had alcohol (76[72%]) etiology cirrhosis, alcoholic hepatitis (58[55%]) precipitating event. Overall, 51(48%) died in-hospital. (n = 9), 1 (n = 39), 2 (n = 24), 3 4 (n = 7), 5 (n = 3) 0%, 26%, 58%, 71%, 100%, 100% respectively (P < 0.001), whereas it 10%, 30%, 79% no-ACLF (n = 21), grades (n = 27), (n = 34) (P < 0.001). Patients (n = 21) higher than they 9 (0% mortality) 12 (17% mortality). Mortality similar between 27 grade (P = 0.462) that comprised 1. Conclusion SOFC is simpler better method CANONIC system APASL criteria.