The Integration of Metabolism and Cell Death

作者: Jonathan L. Coloff , Yuxing Zhao , Jeffrey C. Rathmell

DOI: 10.1007/978-1-60327-381-7_9

关键词:

摘要: Metabolism is a fundamental cellular process necessary for energy production and biosynthesis. While the biochemistry of basic metabolic pathways has been known some time, how state cell regulates fate decisions remained poorly understood. In recent years, metabolism shown to play an integral role in regulation apoptosis, particular via interaction with Bcl-2 family proteins. This chapter focuses on inherent relationships between as well several more intricate mechanisms apoptotic machinery interact determine under variety conditions, including potential apoptosis cancer.

参考文章(77)
Hongmiao Sheng, Jinyi Shao, Raymond N. DuBois, Akt/PKB Activity Is Required for Ha-Ras-mediated Transformation of Intestinal Epithelial Cells Journal of Biological Chemistry. ,vol. 276, pp. 14498- 14504 ,(2001) , 10.1074/JBC.M010093200
Kenneth A. Frauwirth, Craig B. Thompson, Regulation of T lymphocyte metabolism. Journal of Immunology. ,vol. 172, pp. 4661- 4665 ,(2004) , 10.4049/JIMMUNOL.172.8.4661
Zhiwu Lin, Joel M. Weinberg, Ricky Malhotra, Steven E. Merritt, Lawrence B. Holzman, Frank C. Brosius, GLUT-1 reduces hypoxia-induced apoptosis and JNK pathway activation. American Journal of Physiology-endocrinology and Metabolism. ,vol. 278, ,(2000) , 10.1152/AJPENDO.2000.278.5.E958
Constance A. Griffin, Peter L. Pedersen, Anita L. Hawkins, Saroj P. Mathupala, Annette Rempel, Glucose Catabolism in Cancer Cells: Amplification of the Gene Encoding Type II Hexokinase Cancer Research. ,vol. 56, pp. 2468- 2471 ,(1996)
Monica Buzzai, Daniel E Bauer, Russell G Jones, Ralph J DeBerardinis, Georgia Hatzivassiliou, Rebecca L Elstrom, Craig B Thompson, The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β -oxidation Oncogene. ,vol. 24, pp. 4165- 4173 ,(2005) , 10.1038/SJ.ONC.1208622
B Peter-Riesch, M Fathi, W Schlegel, C B Wollheim, Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets. Journal of Clinical Investigation. ,vol. 81, pp. 1154- 1161 ,(1988) , 10.1172/JCI113430
Anna Colell, Jean-Ehrland Ricci, Stephen Tait, Sandra Milasta, Ulrich Maurer, Lisa Bouchier-Hayes, Patrick Fitzgerald, Ana Guio-Carrion, Nigel J. Waterhouse, Cindy Wei Li, Bernard Mari, Pascal Barbry, Donald D. Newmeyer, Helen M. Beere, Douglas R. Green, GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation Cell. ,vol. 129, pp. 983- 997 ,(2007) , 10.1016/J.CELL.2007.03.045
Xuejun Jiang, Xiaodong Wang, Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. Journal of Biological Chemistry. ,vol. 275, pp. 31199- 31203 ,(2000) , 10.1074/JBC.C000405200
Varda Shoshan-Barmatz, Dan Gincel, The voltage-dependent anion channel: characterization, modulation, and role in mitochondrial function in cell life and death. Cell Biochemistry and Biophysics. ,vol. 39, pp. 279- 292 ,(2003) , 10.1385/CBB:39:3:279
Julian J. Lum, Daniel E. Bauer, Mei Kong, Marian H. Harris, Chi Li, Tullia Lindsten, Craig B. Thompson, Growth factor regulation of autophagy and cell survival in the absence of apoptosis Cell. ,vol. 120, pp. 237- 248 ,(2005) , 10.1016/J.CELL.2004.11.046