Cytokines and mechanisms of action of glucocorticoids and aminosalicylates in the treatment of ulcerative colitis and Crohn's disease.

摘要: Medical therapy of ulcerative colitis and Crohn's disease involves the control active inflammation to obtain clinical remission then maintaining that remission. Corticosteroids 5-aminosalicylic acid are mainstay such management. Both have a wide range properties able inhibit many effector mechanisms which potentially involved in mucosal inflammation. In vitro assays, both release variety pro-inflammatory immunoregulatory cytokines. vivo, effects would limit tissue damage, prevent further amplification immune response restore epithelial function.