Prevention of complications in non-insulin-dependent diabetes mellitus (NIDDM)

摘要: It is expected that the number of patients with diabetes mellitus will increase in near future. The high rate microvascular and macrovascular complications developing these place an even higher burden on our healthcare systems. Several pathophysiological factors are involved development complications, among which hyperglycaemia per se, consequent formation advanced glycation end-products (AGEs) intracellular accumulation sorbitol. In addition, hypertension dyslipidaemia also play important role, especially coronary heart disease stroke. major therapeutic goals non-insulin-dependent (NIDDM) to reduce obesity normalise lipid disturbances increased blood pressure, order improve well-being patient risk late diabetic complications. Often, pharmacological treatment necessary, case sulphonylureas, metformin, α-glucosidase inhibitors such as acarbose, or insulin may be employed. believed medical interventions, by their effect improving metabolic control, incidence severity when considering toxic effects glucose AGEs a consequence raised tissue levels. This concept based extrapolation finding Diabetes Control Complications Trial intensive glycaemic control IDDM prevent progression at least like retinopathy nephropathy. There are, however, no long term studies NIDDM show oral antihyperglycaemic agents helps postpone UK Prospective Study whether better either antihyperglycaemics insulin, indeed outcome. other aiming specific factor intervention (hypertension, hyperlipidaemia, oxidation) currently ongoing.