Immune phagocytosis of Plasmodium yoelii-infected erythrocytes by macrophages and eosinophils.

摘要: Unstimulated peritoneal cells from C57Bl mice were allowed to phagocytose in vitro different mixtures of Percoll-separated parasitized and non-parasitized erythrocytes (PE NPE) the blood infected with Plasmodium yoelii presence immune normal serum. Immune serum caused a significant enhancement phagocytosis, both number PE adhering and/or ingested by 100 macrophages latter engaged phagocytosis was increased. The effect more marked when ratio PE/macrophages 5--40/1, but less at 80/1, considerable occurred From 83--100% phagocytosed erythrocytes, even PE/NPE as low 1/15. In system used, unable discriminate between erythrocytes. Eosinophils also observed engage Their activity entirely dependent on never directed against red cells.