Association between Advanced Glycation End Products and Impaired Fasting Glucose: Results from the SALIA Study

摘要: Advanced glycation end products (AGEs) may contribute to the development of type 2 diabetes and related complications, whereas their role in early deterioration glycaemia is unknown. While previous studies used antibody-based methods quantify AGEs, data from tandem mass spectrometry coupled liquid chromatography (LC-MS/MS)-based measurements are limited patients with known diabetes. Here, we LC-MS/MS method test hypothesis that plasma AGE levels higher individuals impaired fasting glucose (IFG) than those normal (NFG). Secondary aims were assess correlations AGEs quantitative markers metabolism biomarkers subclinical inflammation. This study included on 60 women NFG or IFG (n = 30 each, mean age 74 years) German SALIA cohort. Plasma free metabolites (3-deoxyfructose, 3-deoxypentosone, 3-deoxypentulose), two hydroimidazolones, oxidised adducts (carboxymethyllysine, carboxyethyllysine, methionine sulfoxide) Ne-fructosyllysine measured using LC-MS/MS. concentrations all tested did not differ between groups (all p>0.05). Associations glucose, insulin HOMA-IR as a measure resistance weak (r -0.2 0.2, The association 3-deoxyglucosone-derived hydroimidazolone several proinflammatory disappeared upon adjustment for multiple testing. In conclusion, assessed by neither increased nor associated parameters inflammation our study. Thus, these argue against strong effects stages metabolism.