Dynamics of antigen presentation to transgene product-specific CD4+ T cells and of Treg induction upon hepatic AAV gene transfer
作者： George Q Perrin , Irene Zolotukhin , Alexandra Sherman , Moanaro Biswas , Ype P de Jong
DOI: 10.1038/MTM.2016.83
关键词:
摘要: … -derived antigens and inducing Treg. There is … Treg, we designed experiments using T cell receptor-transgenic CD4 + T cells with specificity to a cytoplasmic protein expressed from AAV …
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sci-hub.se 参考文章(50)
Ashley T. Martino, Roland W. Herzog, Ignacio Anegon, Oumeya Adjali, Measuring Immune Responses to Recombinant AAV Gene Transfer Methods of Molecular Biology. ,vol. 807, pp. 259- 272 ,(2011) , 10.1007/978-1-61779-370-7_11
Mahzad Akbarpour, Kevin S. Goudy, Alessio Cantore, Fabio Russo, Francesca Sanvito, Luigi Naldini, Andrea Annoni, Maria Grazia Roncarolo, Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs. Science Translational Medicine. ,vol. 7, ,(2015) , 10.1126/SCITRANSLMED.AAA3032
Ekaterina Breous, Suryanarayan Somanathan, Luk H. Vandenberghe, James M. Wilson, Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver Hepatology. ,vol. 50, pp. 612- 621 ,(2009) , 10.1002/HEP.23043
Meijuan Zheng, Jiali Yu, Zhigang Tian, Characterization of the liver-draining lymph nodes in mice and their role in mounting regional immunity to HBV Cellular & Molecular Immunology. ,vol. 10, pp. 143- 150 ,(2013) , 10.1038/CMI.2012.59
Jonathan D. Finn, Margareth C. Ozelo, Denise E. Sabatino, Helen W. G. Franck, Elizabeth P. Merricks, Julie M. Crudele, Shangzhen Zhou, Haig H. Kazazian, David Lillicrap, Timothy C. Nichols, Valder R. Arruda, Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy Blood. ,vol. 116, pp. 5842- 5848 ,(2010) , 10.1182/BLOOD-2010-06-288001
Brad E. Hoffman, Eric Dobrzynski, Lixin Wang, Lauren Hirao, Federico Mingozzi, Ou Cao, Roland W. Herzog, Muscle as a target for supplementary factor IX gene transfer. Human Gene Therapy. ,vol. 18, pp. 603- 613 ,(2007) , 10.1089/HUM.2007.042
Andrea Annoni, Brian D. Brown, Alessio Cantore, Lucia Sergi Sergi, Luigi Naldini, Maria-Grazia Roncarolo, In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance Blood. ,vol. 114, pp. 5152- 5161 ,(2009) , 10.1182/BLOOD-2009-04-214569
Brad E Hoffman, Ashley T Martino, Brandon K Sack, Ou Cao, Gongxian Liao, Cox Terhorst, Roland W Herzog, None, Nonredundant Roles of IL-10 and TGF-β in Suppression of Immune Responses to Hepatic AAV-Factor IX Gene Transfer Molecular Therapy. ,vol. 19, pp. 1263- 1272 ,(2011) , 10.1038/MT.2011.33
E. Dobrzynski, J. C. Fitzgerald, O. Cao, F. Mingozzi, L. Wang, R. W. Herzog, Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 4592- 4597 ,(2006) , 10.1073/PNAS.0508685103
Brandon K Sack, Roland W Herzog, Cox Terhorst, David M Markusic, Development of gene transfer for induction of antigen-specific tolerance Molecular therapy. Methods & clinical development. ,vol. 1, pp. 14013- 14013 ,(2014) , 10.1038/MTM.2014.13