Wild-type p53 protects normal cells against apoptosis induced by thiostrepton

摘要: Cancer cells are generally more sensitive to anticancer drugs than normal cells. This provides the rationale for using specifically against tumor cells, but explanation specificity is often elusive. In this study, we compared sensitivity of BJ human fibroblasts, fibroblasts with p53 knockdown and corresponding immortal/oncogenic cell lines inactivated drug-induced apoptosis. We found that only have wild-type were resistant thiazole antibiotic, thiostrepton, suggesting plays an antiapoptotic role in case status, not transformation per se determines their thiostrepton possibly other drugs. Since mutated 50% cancers, may selectively kill cancer, These data imply can protect from death its mutations sensitize cancer anti-neoplastic agents.