The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice.
作者： T.L. Torzsas , C.W.C. Kendall , M. Sugano , Y. Iwamoto , A.V. Rao
DOI: 10.1016/0278-6915(95)00083-6
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摘要: Abstract The effect of dietary chitosan, a fibre animal origin, on the induction and development colonic precursor lesions was determined in CFl mice. Over 2-wk pretreatment period, one group mice given azoxymethane (four injections 5 mg/kg body weight) other treated with saline. Subsequent to carcinogen or saline were randomized into three groups: (i) control AIN-76 diet; (ii) diet 2% low molecular weight chitosan (LMWC); (iii) high (HMWC). Mice maintained this for 6 wk. fed containing HMWC had significant reductions number aberrant crypt foci, cell proliferation, height circumference epithelium (P
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