Myocardial lactate release during ischemia in swine. Relation to regional blood flow.

摘要: To determine the relation between regional myocardial blood flow, contractile function, and lactate release during mild-to-moderate ischemia, nine open-chest swine were instrumented for measurement of flow (microsphere method), function (sonomicrometry), hemodynamics. L-[1-14C]Lactate or L-[U-13C]lactate was infused intravenously using a primed continuous infusion technique to quantify release. D-[U-13C]glucose D-[6-14C]glucose simultaneously contribution exogenous glucose Graded coronary ischemia (two three levels) created in left anterior descending arterial distribution by mechanically constricting artery five animals decreasing through cannulated four animals. In all animals, subendocardial 0.99 +/- 0.21 (ml/min)/g control 0.34 0.14 most severe grade underperfusion (p less than 0.001) distribution. Regional 0.15 0.09 1.19 0.75 mumols/ml, respectively 0.003). A highly significant inverse correlation observed graded reductions (r = -0.71, p 0.001). Results from sonomicrometry showed reduction ventricular wall flow. The arterial-venous difference increased significantly with distribution, 0.56 0.37 mumols/ml also significantly; 0.04 0.03 came compared 0.64 0.59 0.02). positive exists 0.96, summary, these data demonstrate close ischemia.