Myocardial Ischemia Induced by Rapid Atrial Pacing Causes Troponin T Release Detectable by a Highly Sensitive Assay

摘要: Objectives The purpose of this study was to assess whether: 1) very small increases in troponin T, measured by a new highly sensitive cardiac T (hs-cTnT), may reflect ischemia without necrosis; and 2) serial changes can discriminate from other causes (cTnT) release. Background A hs-cTnT assay offers greater sensitivity than current assays. Methods Nineteen patients referred for diagnostic catheterization underwent cannulation the coronary sinus (CS). Serial CS peripheral plasma samples were obtained at multiple time points during after incremental rapid atrial pacing. cTnT quantified using both standard pre-commercial assay. Ischemia determined presence significant artery disease (CAD) myocardial lactate release with Results concentrations blood increased median 6.8 pg/ml prior pacing 15.6 60 min termination (p Conclusions Brief periods ischemia, frank infarction, cause low-level release, are common work, even among objective evidence or obstructive CAD. Additional research is needed before assays widely adopted management subjects chest pain syndromes.